Gif Central boasts hundreds of funny animated gifs. Only the best of the best make it onto this site, with most of them having an accompanying source. No tumblr-esque one-second-long disappointments. No obscure titles or descriptions.
An animated reaction gif of Captain Hector Barbossa saying "I'm disinclined to acquiesce to your request. It means no." This is from the Pirates of the Caribbean film series. The girl in question is Keira Knightley.